Commentary on Tsokas et al

In nearly two decades of work, neuroscientist Todd Sacktor has argued that the protein PKM-ζ regulates memory maintenance in rodents. However, 3 years ago two papers (here and here) showed that mice lacking PKM-ζ could remember normally, and severely undermined PKM-ζ’s status as preeminent memory molecule. In response to these papers, a new study by Sacktor’s group reveals that another isoform of the protein acts as backup when PKM-ζ is knocked out. We have written a commentary on this new chapter in the PKM-ζ controversy. NV

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