Below is a sample of the work our lab is involved in.
Memories of everyday life-of people, places and events-initially depend on the medial temporal lobe system, including the hippocampus. However, as these memories mature, they are thought to become increasingly dependent on other brain regions such as the cortex. Our recent work has used brain mapping, mouse-genetic and pharmacological approaches to understand how new memories in the hippocampus are transformed into lifelong, or remote, memories in cortical networks. Read More
Throughout adulthood, new neurons are continuously generated in the subgranular zone of the hippocampus. Our studies focus on the contribution of these new neurons to memory processing in the dentate gyrus. Read More
Spatial learning tasks are a powerful way of assaying hippocampal function. For example, the Morris Water Maze (MWM), deveoped by Richard Morris of the University of Edinburgh in 1984, requires animals to learn the location of a submerged platform in a pool of water. We are working on new methods to measure learning in the water maze and other similar tasks. Read More