Okay, Blue Jays!

The 2016 lab outing to the Rogers Centre. Sungmo in charge of the selfie.baseball 2016.jpg

CAN in the 6ix!

Our lab was well represented at this week’s Canadian Association for Neuroscience meeting in Toronto. Pictured at the opening night reception are (L to R): Frances, Valentina, Adam (@adam_rams), Lina (@lmntran), Emily, Alex (@Neurochatter), Colleen and Gisella (@InAnOther).CAN 2016

Bonny, MSc

Congratulations to Bonny who successfully defended her MSc thesis today! Selfie-ed here with her exam committee (PF, Junchul Kim, Zhengping Jia, Min Zhuo and Lu-Yang Wang).bonny

Kids Science day

Albert, Lina and Patrick from the J/F labs doing a great job teaching local highschoolers all about memory at Kids Science day at SickKids.science kids

Lab Selfie day 2016

The members of the frankland/josselyn lab:selifie 2016

Commentary on Danielson et al (2016)

A new paper  by Mazen Kheirbek and colleagues using in vivo calcium imaging to monitor the activity of newborn hippocampal neurons as mice discriminated similar contexts. Our commentary in Neuron.
neuron preview

Team neurogenesis

Participants at the recent Cancun neurogenesis conference in their resort-wear.

FUSION neurogenesis conference, Cancun

Nico Toni presenting at this week’s neurogenesis conference in Cancun, Mexico.cancun toni

Why forgetting is good

epp_fig3In the last few years our lab has been interested in how hippocampal neurogenesis regulates forgetting (see Frankland, Akers). The idea is that as new neurons integrate into hippocampal circuits they remodel those circuits and render information already stored within those circuits harder to access. But is this neurogenesis-mediated clearance good for memory? In every day life we think of forgetting as something bad, a failure of memory.

In this paper, Jonathan Epp finds that increasing hippocampal neurogenesis weakens existing memories and, in doing so, facilitates the encoding of new, conflicting (but not non-conflicting) information in mice. Conversely, decreasing neurogenesis stabilizes existing memories, and impedes the encoding of new, conflicting information. These results suggest that reduced proactive interference is an adaptive benefit of neurogenesis-induced forgetting.

Jonathan’s paper is published in Nature Communications.


Adventures at Route 28 at Chiemsee

Once every 2-3 years, Gerd Kempermann gathers a bunch of neurogenesis researchers from around the world (students and PIs), takes them to an island with no TVs and barely any wifi and asks them to solve the world’s problems figure out what neurogenesis in the adult brain is good for. I and former Frankland lab member Jason Snyder were honored to participate. Some pictures of (clockwise) Magdalena Goetz, Jason, the island and Benedikt Berninger  below.chiemsee 1